Enhanced immunogenicity and dose-sparing efficacy of self-amplifying RNA vaccines against seasonal influenza across subtypes

Recent clinical data on seasonal influenza mRNA vaccines have demonstrated suboptimal efficacy against the influenza B virus (IBV). We employed sequence optimization strategies that successfully enhanced the antigen expression of hemagglutinin (HA) and developed mRNA vaccine candidates targeting the...

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Auteurs principaux:	Mengting Huang, Yun Quan, Ruyi Chen, Hao Gu, Wenjun Song, Feng Zhu, Simin Feng, Jinzhong Lin, Jing Lu, Xuechun Li, Wansheng Li, Qianyu Pan, Hongli Li, Lei Sun, Tao Jiang, Bihui Zhang, Xinqian Yin, Dandan Wei, Changrong Yang, Donglan Liu, Zhongfang Wang, Weixin Jia, Jincun Zhao, Jieshi Yu, Xiaobo Li, Xuedong Yu, Xiaojing Yue, Chufang Li, Fan Bu, Zhichao Miao, Qiong Zhang
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis Group 2026-12-01
Collection:	Emerging Microbes and Infections
Sujets:	Self-amplifying RNA influenza B virus dose-sparing seasonal influenza trivalent vaccine
Accès en ligne:	https://www.tandfonline.com/doi/10.1080/22221751.2026.2668752
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