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Enhanced immunogenicity and dose-sparing efficacy of self-amplifying RNA vaccines against seasonal influenza across subtypes

Recent clinical data on seasonal influenza mRNA vaccines have demonstrated suboptimal efficacy against the influenza B virus (IBV). We employed sequence optimization strategies that successfully enhanced the antigen expression of hemagglutinin (HA) and developed mRNA vaccine candidates targeting the...

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Asıl Yazarlar: Mengting Huang, Yun Quan, Ruyi Chen, Hao Gu, Wenjun Song, Feng Zhu, Simin Feng, Jinzhong Lin, Jing Lu, Xuechun Li, Wansheng Li, Qianyu Pan, Hongli Li, Lei Sun, Tao Jiang, Bihui Zhang, Xinqian Yin, Dandan Wei, Changrong Yang, Donglan Liu, Zhongfang Wang, Weixin Jia, Jincun Zhao, Jieshi Yu, Xiaobo Li, Xuedong Yu, Xiaojing Yue, Chufang Li, Fan Bu, Zhichao Miao, Qiong Zhang
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Taylor & Francis Group 2026-12-01
Seri Bilgileri:Emerging Microbes and Infections
Konular:
Self-amplifying RNA
influenza B virus
dose-sparing
seasonal influenza
trivalent vaccine
Online Erişim:https://www.tandfonline.com/doi/10.1080/22221751.2026.2668752
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