CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

Abstract Background Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However, mitochondria are required for intracellular oxygenation and norm...

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Detalhes bibliográficos

Principais autores:	Luke W. Thomas, Jenna M. Stephen, Cinzia Esposito, Simon Hoer, Robin Antrobus, Afshan Ahmed, Hasan Al-Habib, Margaret Ashcroft
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-03-01
coleção:	Cancer & Metabolism
Assuntos:	Coiled-coil-helix-coiled-coil-helix domain-containing 4 (CHCHD4) Hypoxia HIF-1α Mitochondria Respiratory chain Disulfide relay system
Acesso em linha:	http://link.springer.com/article/10.1186/s40170-019-0194-y
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