Mutant CHCHD10 causes an extensive metabolic rewiring that precedes OXPHOS dysfunction in a murine model of mitochondrial cardiomyopathy

Summary: Mitochondrial cardiomyopathies are fatal diseases, with no effective treatment. Alterations of heart mitochondrial function activate the mitochondrial integrated stress response (ISRmt), a transcriptional program affecting cell metabolism, mitochondrial biogenesis, and proteostasis. In huma...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Nicole M. Sayles, Nneka Southwell, Kevin McAvoy, Kihwan Kim, Alba Pesini, Corey J. Anderson, Catarina Quinzii, Suzanne Cloonan, Hibiki Kawamata, Giovanni Manfredi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2022-03-01
Colecção:	Cell Reports
Assuntos:	coiled-coil-helix-coiled-coil-helix domain containing 10 CHCHD10 mitochondria heart, cardiomyopathy integrated stress response metabolic rewiring
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S221112472200208X
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!