Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD). However, whether LRRK2 mutations cause PD and degeneration of dopaminergic (DA) neurons via a toxic gain-of-function or a loss-of-function mechanism is unresolved and has pivotal implicat...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Jongkyun Kang, Guodong Huang, Long Ma, Youren Tong, Anu Shahapal, Phoenix Chen, Jie Shen
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	eLife Sciences Publications Ltd 2024-06-01
Sarja:	eLife
Aiheet:	LRRK1 LRRK2 dopaminergic neuron conditional knock-out mice substantia nigra pars compacta Parkinson's disease
Linkit:	https://elifesciences.org/articles/92673
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!