Cell-autonomous role of leucine-rich repeat kinase in the protection of dopaminergic neuron survival

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson’s disease (PD). However, whether LRRK2 mutations cause PD and degeneration of dopaminergic (DA) neurons via a toxic gain-of-function or a loss-of-function mechanism is unresolved and has pivotal implicat...

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Autores principales:	Jongkyun Kang, Guodong Huang, Long Ma, Youren Tong, Anu Shahapal, Phoenix Chen, Jie Shen
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	eLife Sciences Publications Ltd 2024-06-01
Colección:	eLife
Materias:	LRRK1 LRRK2 dopaminergic neuron conditional knock-out mice substantia nigra pars compacta Parkinson's disease
Acceso en línea:	https://elifesciences.org/articles/92673
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