Checkpoint kinase 2 coordinates autophagy activation and Aurora kinase A degradation to regulate primary cilia for cell invasion

Abstract Background Checkpoint kinase 2 (CHEK2) is a tumor suppressor that safeguards genome integrity in the nucleus. It is also localized at the mother centriole. But the role of CHEK2 in this structure remains unclear. The primary cilium acts as a sensory organelle that regulates various aspects...

Olles dieđut

Bibliográfalaš dieđut

Váldodahkkit:	Chia-Yih Wang, Yu-Ying Chao, Ting-Yu Chen, Ruei-Ci Lin, Hui-Man Tsai, Hsiao-Han Huang, Zi-Rong Chen, Fu-I Lu, Yu-Chi Su, Bon-chu Chung
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2026-05-01
Ráidu:	Cell Communication and Signaling
Fáttát:	Trophoblast invasion Autophagy Axoneme Aurora A Pancreatic cancer Nutrient deprivation
Liŋkkat:	https://doi.org/10.1186/s12964-026-02953-6
Fáddágilkorat:	Lasit fáddágilkoriid Eai fáddágilkorat, Lasit vuosttaš fáddágilkora!