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Restoration of primary cilia in obese adipose-derived mesenchymal stem cells by inhibiting Aurora A or extracellular signal-regulated kinase

Abstract Background Obesity impairs a variety of cell types including adipose-derived mesenchymal stem cells (ASCs). ASCs are indispensable for tissue homeostasis/repair, immunomodulation, and cell renewal. It has been demonstrated that obese ASCs are defective in differentiation, motility, immunomo...

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Autors principals: Andreas Ritter, Nina-Naomi Kreis, Susanne Roth, Alexandra Friemel, Lukas Jennewein, Christine Eichbaum, Christine Solbach, Frank Louwen, Juping Yuan
Format: Artigo
Idioma:Inglês
Publicat: BMC 2019-08-01
Col·lecció:Stem Cell Research & Therapy
Matèries:
Adipose-derived mesenchymal stem cells
Primary cilium
Obesity
Aurora A
Extracellular signal-regulated kinase 1/2
Glycogen synthase kinase 3 beta
Accés en línia:http://link.springer.com/article/10.1186/s13287-019-1373-z
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