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The nicotinamide phosphoribosyltransferase inhibitor FK866 restricts influenza A virus replication by perturbing viral polymerase activity

ABSTRACT Nicotinamide phosphoribosyltransferase (NAMPT), a key rate-limiting enzyme in NAD+ synthesis, plays important roles in various physiological and pathological processes. However, the function and underlying mechanisms of NAMPT in influenza A virus (IAV) infection and pathogenesis remain ambi...

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Principais autores: Changjie Lv, Shuang Wang, Mingyue Song, Jianmei Wu, Wanxin Wei, Guijie Guo
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2026-07-01
Serier:Journal of Virology
Fag:
influenza A virus
NAMPT
FK866
PB1
virus replication
Online adgang:https://journals.asm.org/doi/10.1128/jvi.00591-26
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