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Obatoclax Rescues FUS-ALS Phenotypes in iPSC-Derived Neurons by Inducing Autophagy

Aging is associated with the disruption of protein homeostasis and causally contributes to multiple diseases, including amyotrophic lateral sclerosis (ALS). One strategy for restoring protein homeostasis and protecting neurons against age-dependent diseases such as ALS is to de-repress autophagy. BE...

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Principais autores: Cristina Marisol Castillo Bautista, Kristin Eismann, Marc Gentzel, Silvia Pelucchi, Jerome Mertens, Hannah E. Walters, Maximina H. Yun, Jared Sterneckert
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-09-01
Serier:Cells
Fag:
phenotypic screening
autophagy
FUS
amyotrophic lateral sclerosis
Online adgang:https://www.mdpi.com/2073-4409/12/18/2247
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