Auranofin and iodoquinol as promising repurposing drugs against filamentous fungi: antifungal activity and cellular alterations

ABSTRACT Opportunistic fungal infections have become an increasing health threat, particularly in immunocompromised individuals, due to their high virulence, biofilm-forming capacity, and resistance to conventional antifungals. Given the limited therapeutic arsenal, drug repurposing represents a pro...

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Main Authors:	Mariana Ingrid Dutra da Silva Xisto, Rodrigo Rollin-Pinheiro, Paloma Cristina Malfetano da Rosa, Johnatha de Souza Santos, Nicole Ferreira da Silva Irmão, Julia Almeida Abi Abib, Victor Pereira Rochetti, Yuri de Castro Almeida, Giulia Maria Pires dos Santos Freitas, Jefferson Cypriano, Eliana Barreto-Bergter
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology 2026-04-01
Series:	Microbiology Spectrum
Subjects:	auranofin iodoquinol fungal infections repurposing drugs antifungal therapy
Online Access:	https://journals.asm.org/doi/10.1128/spectrum.03356-25
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