Structure–Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets. Voltage-gated sodium channels (NaV) are often targeted by these peptides to allosterically promote opening or closing of the chan...

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Bibliografiske detaljer

Principais autores:	Fernanda C. Cardoso, Richard J. Lewis
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2019-04-01
Serier:	Frontiers in Pharmacology
Fag:	spider venoms ICK peptides voltage-gated ion channels structure–activity relationship novel drugs
Online adgang:	https://www.frontiersin.org/article/10.3389/fphar.2019.00366/full
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