Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.

Vaccinia virus (VACV) protein N1 is an intracellular virulence factor and belongs to a family of VACV B-cell lymphoma (Bcl)-2-like proteins whose members inhibit apoptosis or activation of pro-inflammatory transcription factors, such as interferon (IFN) regulatory factor-3 (IRF-3) and nuclear factor...

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Principais autores:	Carlos Maluquer de Motes, Samantha Cooray, Hongwei Ren, Gabriel M F Almeida, Kieran McGourty, Mohammad W Bahar, David I Stuart, Jonathan M Grimes, Stephen C Graham, Geoffrey L Smith
格式:	Artigo
語言:	Inglês
出版:	Public Library of Science (PLoS) 2011-12-01
叢編:	PLoS Pathogens
在線閱讀:	https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002430&type=printable
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