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Design of a multi-epitope vaccine against drug-resistant mycobacterium tuberculosis and mycobacterium bovis using reverse vaccinology

Abstract The global burden of Mycobacterium tuberculosis (M. tuberculosis) and Mycobacterium bovis (M. bovis), the rise of drug-resistant strains, necessitates an urgent need for developing more effective vaccines. This study employed an in-silico approach to design a multi-epitope vaccine targeting...

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Principais autores: Eva Akurut, Yahaya Gavamukulya, Julius Mulindwa, Moses Isiagi, Ronald Galiwango, Mudarshiru Bbuye, Ibra Lujumba, Davis Kiberu, Patricia Nabisubi, Grace Kebirungi, Andrew Kambugu, Barbara Castelnuovo, Gyaviira Nkurunungi, Daudi Jjingo, Brenda Oketch, David Patrick Kateete, Gerald Mboowa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-07-01
coleção:Scientific Reports
Assuntos:
Mycobacterium tuberculosis
Mycobacterium bovis
Vaccines
BCG
Reverse vaccinology
Molecular Docking
Acesso em linha:https://doi.org/10.1038/s41598-025-11768-3
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