Secretory expression of cyclohexanone monooxygenase by methylotrophic yeast for efficient omeprazole sulfide bio-oxidation

Abstract Prochiral pyrmetazole can be asymmetrically oxidized into (S)-omeprazole, a proton pump inhibitor that is used to treat gastroesophageal reflux, by an engineered cyclohexanone monooxygenase (CHMO Acineto -Mut) that has high stereoselectivity. CHMO Acineto -Mut is produced by heterologous ex...

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Autori principali:	Ya-Jing Li, Yu-Cong Zheng, Qiang Geng, Feng Liu, Zhi-Jun Zhang, Jian-He Xu, Hui-Lei Yu
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	SpringerOpen 2021-08-01
Serie:	Bioresources and Bioprocessing
Soggetti:	Cyclohexanone monooxygenase Omeprazole sulfoxide Pichia pastoris Secretory expression Asymmetric oxidation
Accesso online:	https://doi.org/10.1186/s40643-021-00430-1
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