ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation

Abstract Background Dysfunctional p53 signaling is one of the major causes of hepatocellular carcinoma (HCC) tumorigenesis and development, but the mechanisms underlying p53 inactivation in HCC have not been fully clarified. The role of Krüppel-associated box (KRAB)-type zinc-finger protein ZNF498 i...

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Detalhes bibliográficos

Principais autores:	Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-02-01
Colecção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	ZNF498 p53 Phosphorylation Apoptosis Ferroptosis Hepatocellular carcinoma
Acesso em linha:	https://doi.org/10.1186/s13046-022-02288-3
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