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ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation

Abstract Background Dysfunctional p53 signaling is one of the major causes of hepatocellular carcinoma (HCC) tumorigenesis and development, but the mechanisms underlying p53 inactivation in HCC have not been fully clarified. The role of Krüppel-associated box (KRAB)-type zinc-finger protein ZNF498 i...

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Principais autores: Xiuyuan Zhang, Qijian Zheng, Xiuying Yue, Zhanna Yuan, Jiming Ling, Yanzhi Yuan, Yanying Liang, Aihua Sun, Yuchen Liu, Hui Li, Kaikun Xu, Fuchu He, Jian Wang, Jin Wu, Chunling Zhao, Chunyan Tian
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-02-01
Serier:Journal of Experimental & Clinical Cancer Research
Fag:
ZNF498
p53
Phosphorylation
Apoptosis
Ferroptosis
Hepatocellular carcinoma
Online adgang:https://doi.org/10.1186/s13046-022-02288-3
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