Regulation of presynaptic Ca2+ channel abundance at active zones through a balance of delivery and turnover

Voltage-gated Ca2+ channels (VGCCs) mediate Ca2+ influx to trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release probability (Pr), a key presynaptic determinant of synaptic strength. Although bios...

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Principais autores:	Karen L Cunningham, Chad W Sauvola, Sara Tavana, J Troy Littleton
格式:	Artigo
語言:	Inglês
出版:	eLife Sciences Publications Ltd 2022-07-01
叢編:	eLife
主題:	active zone synapse calcium channel synaptic plasticity VGCC NMJ
在線閱讀:	https://elifesciences.org/articles/78648
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