Regulation of presynaptic Ca2+ channel abundance at active zones through a balance of delivery and turnover

Voltage-gated Ca2+ channels (VGCCs) mediate Ca2+ influx to trigger neurotransmitter release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release probability (Pr), a key presynaptic determinant of synaptic strength. Although bios...

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Detalhes bibliográficos

Principais autores:	Karen L Cunningham, Chad W Sauvola, Sara Tavana, J Troy Littleton
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2022-07-01
Colecção:	eLife
Assuntos:	active zone synapse calcium channel synaptic plasticity VGCC NMJ
Acesso em linha:	https://elifesciences.org/articles/78648
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