Viable cell density as an indicator for dynamic feeding strategy in fed-batch and perfusion CHO cell culture
Abstract The general approach to industrial production of monoclonal antibodies is fed-batch culture using Chinese Hamster Ovary (CHO) cells. Perfusion culture is also attracting attention as a next-generation culture method. In these culture methods, optimization of amino acid and glucose concentra...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Portfolio
2025-12-01
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| Collection: | Scientific Reports |
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| Accès en ligne: | https://doi.org/10.1038/s41598-025-28316-8 |
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