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Sec17/Sec18 act twice, enhancing membrane fusion and then disassembling cis-SNARE complexes

At physiological protein levels, the slow HOPS- and SNARE-dependent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without requiring ATP hydrolysis. To stimulate, Sec17 needs its central residues which bind the 0-layer of the SNARE complex and its N-terminal a...

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Principais autores: Hongki Song, Amy Orr, Mengtong Duan, Alexey J Merz, William Wickner
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2017-07-01
Serier:eLife
Fag:
membrane fusion
yeast vacuoles
SNAREs
Sec17/aSNAP
Sec18/NSF
Online adgang:https://elifesciences.org/articles/26646
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