De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA

Background & Aims: Chronic HBV infection cannot be cured by current therapeutics owing to their limited ability to reduce covalently closed circular (ccc)DNA levels in the livers of infected individuals. Therefore, greater understanding of the molecular determinants of cccDNA formation and persi...

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Hlavní autoři:	Thomas Tu, Benno Zehnder, Bingqian Qu, Stephan Urban
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-02-01
Edice:	JHEP Reports
Témata:	Covalently closed circular DNA Myrcludex B Bulevirtide Hepcludex HBV persistence Core protein
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2589555920301294
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