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Bile-Acid-Appended Triazolyl Aryl Ketones: Design, Synthesis, In Vitro Anticancer Activity and Pharmacokinetics in Rats

A library of bile-acid-appended triazolyl aryl ketones was synthesized and characterized by detailed spectroscopic techniques such as <sup>1</sup>H and <sup>13</sup>C NMR, HRMS and HPLC. All the synthesized conjugates were evaluated for their cytotoxicity at 10 µM against MCF-7 (human breast adenoca...

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Principais autores: Devesh S. Agarwal, Samrat Mazumdar, Kishan S. Italiya, Deepak Chitkara, Rajeev Sakhuja
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2021-09-01
Serier:Molecules
Fag:
bile acid
anticancer
cytotoxicity
apoptosis
pharmacokinetic study
Online adgang:https://www.mdpi.com/1420-3049/26/19/5741
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