Expression of TIM-3 and Gal-9 Immune Checkpoints in Chronic Lymphocytic Leukemia: The Potential Role of Interleukin-27

Background: Chronic lymphocytic leukemia (CLL) is characterized by malignant B lymphocyte accumulation and progressive immune dysfunction. The immune checkpoint molecule TIM-3 and its ligand galectin-9 (Gal-9) contribute to T cell exhaustion, impairing anti-tumour immunity. Interleukin-27 (IL-27) ha...

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Detalhes bibliográficos

Principais autores:	Ewelina Wędrowska, Tomasz Wandtke, Bartosz Ulaszewski, Edyta Cichocka, Robert Dębski, Piotr Kopiński, Jan Styczyński, Grzegorz Przybylski
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2025-10-01
Colecção:	Current Issues in Molecular Biology
Assuntos:	chronic lymphocytic leukemia immune checkpoints TIM-3 galectin-9 interleukin-27 T cell exhaustion
Acesso em linha:	https://www.mdpi.com/1467-3045/47/11/881
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