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Expression of TIM-3 and Gal-9 Immune Checkpoints in Chronic Lymphocytic Leukemia: The Potential Role of Interleukin-27

Background: Chronic lymphocytic leukemia (CLL) is characterized by malignant B lymphocyte accumulation and progressive immune dysfunction. The immune checkpoint molecule TIM-3 and its ligand galectin-9 (Gal-9) contribute to T cell exhaustion, impairing anti-tumour immunity. Interleukin-27 (IL-27) ha...

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Principais autores: Ewelina Wędrowska, Tomasz Wandtke, Bartosz Ulaszewski, Edyta Cichocka, Robert Dębski, Piotr Kopiński, Jan Styczyński, Grzegorz Przybylski
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-10-01
coleção:Current Issues in Molecular Biology
Assuntos:
chronic lymphocytic leukemia
immune checkpoints
TIM-3
galectin-9
interleukin-27
T cell exhaustion
Acesso em linha:https://www.mdpi.com/1467-3045/47/11/881
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