Effect of Lysosomotropic Polyamineoxidase Inhibitor MDL-72527 on Platelet Activation

Background/Aims: The polyamine oxidase inhibitor MDL-72527 (N1,N4-bis(2,3-butadienyl)-1,4-butanediamine) were expected to increase the abundance of spermine, a powerful inhibitor of platelet activation. Nothing is known, however, on the sensitivity of platelet function and survival to MDL-72527 expo...

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Bibliografiske detaljer

Principais autores:	Guoxing Liu, Hang Cao, Guilai Liu, David Heinzmann, Hong Chen, Anja T. Umbach, Meinrad Gawaz, Florian Lang
Format:	Artigo
Sprog:	Inglês
Udgivet:	Cell Physiol Biochem Press GmbH & Co KG 2016-05-01
Serier:	Cellular Physiology and Biochemistry
Fag:	Collagen related peptide, platelet activation Platelet degranulation, integrin activation, cytosolic Ca2+ concentration Reactive oxygen species Phosphatidylserine translocation
Online adgang:	http://www.karger.com/Article/FullText/443108
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