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Network pharmacology, molecular docking, and in vivo experiments reveal the effects of Polygonati Rhizoma on periodontitis

Abstract This study explores Polygonati Rhizoma’s therapeutic potential against periodontitis using network pharmacology, molecular docking, and experimental validation to uncover its mechanisms. Active ingredients and targets of Polygonati Rhizoma were sourced from TCMSP and DrugBank, while periodo...

Cur síos iomlán

Sábháilte in:
Príomhchruthaitheoirí: Qunli Ren, Xiaolan Li, Jingtong Wang, Qian Wang, Fangzhou Liu, Bin Zeng, Pan Gao, Yingzhe Li, Menglin Song, Zhongjia Tian, Bin Chen, Jianguo Liu
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2026-02-01
Sraith:Scientific Reports
Ábhair:
Polygonati Rhizoma
Periodontitis
Network pharmacology
Molecular docking
Gut microbiota
Alveolar bone loss
Rochtain ar líne:https://doi.org/10.1038/s41598-026-40597-1
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