Optimized nuclei isolation and snRNA-seq reveal oligodendrocyte pathway dysregulation in MOGHE brain tissue from pediatric patients

Abstract Single-cell RNA sequencing (scRNA-seq) is a powerful tool for exploring cellular diversity, but isolating intact cells from complex tissues like the brain remains challenging. Single-nucleus RNA sequencing (snRNA-seq) overcomes these limitations by profiling nuclear RNA from frozen or archi...

Descripció completa

Dades bibliogràfiques

Autors principals:	Clara Tuccari di San Carlo, Roberto Semeraro, Valentina Cetica, Dalila De Vita, Benedetta Mazzinghi, Antonio Falace, Cristiana Pelorosso, Paola Romagnani, Alberto Magi, Renzo Guerrini, Valerio Conti
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-05-01
Col·lecció:	Scientific Reports
Accés en línia:	https://doi.org/10.1038/s41598-026-54112-z
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!