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Intranasal Immunization with Recombinant Hemagglutinin of Influenza A/H5 Virus Complexed with Novochizol Induces Virus-Neutralizing Antibodies and Protects Animals from Lethal Viral Challenge

<b>Background:</b> Avian influenza is a critical zoonotic infection threatening both the poultry industry and global public health. While traditional intramuscular vaccines elicit systemic immunity, they often fail to provide robust local protection at mucosal surfaces. There is thus significant int...

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Main Authors: Nadezhda B. Rudometova, Ksenia I. Ivanova, Vladislav V. Fomenko, Andrey P. Rudometov, Lyubov A. Kisakova, Denis N. Kisakov, Elena V. Yakovleva, Vladimir A. Yakovlev, Kristina P. Makarova, Danil I. Vakhitov, Mariya B. Borgoyakova, Ekaterina V. Starostina, Boris N. Zaitsev, Victoria R. Litvinova, Stepan A. Pyankov, Tatiana N. Ilyicheva, Alexander A. Ilyichev, Andrei S. Gudymo, Vasiliy Yu. Marchenko, Nariman F. Salakhutdinov, Aleksandr P. Agafonov, Larisa I. Karpenko
Format: Artigo
Language:Inglês
Published: MDPI AG 2026-05-01
Series:Pharmaceutics
Subjects:
influenza A/H5 virus
hemagglutinin
intranasal immunization
Novochizol
Online Access:https://www.mdpi.com/1999-4923/18/6/669
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