Cytotoxicity of Donor Natural Killer Cells to Allo-Reactive T Cells Are Related With Acute Graft-vs.-Host-Disease Following Allogeneic Stem Cell Transplantation

Objectives: The mechanism and immunoregulatory role of human natural killer (NK) cells in acute graft-vs.-host-disease (aGVHD) remains unclear. This study quantitatively analyzed the cytotoxicity of donor NK cells toward allo-reactive T cells, and investigated their relationship with acute GVHD (aGV...

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Autori principali:	Lixia Sheng, Qitian Mu, Xiaoqing Wu, Shujun Yang, Huiling Zhu, Jiaping Wang, Yanli Lai, Hao Wu, Ye Sun, Yongxian Hu, Huarui Fu, Yi Wang, Kaihong Xu, Yongcheng Sun, Yanli Zhang, Ping Zhang, Miao Zhou, Binbin Lai, Zhijuan Xu, Minjie Gao, Yi Zhang, Guifang Ouyang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2020-07-01
Serie:	Frontiers in Immunology
Soggetti:	natural killer cells cytotoxicity CD107a graft vs. host disease allogeneic hematopoietic stem cell transplantation
Accesso online:	https://www.frontiersin.org/article/10.3389/fimmu.2020.01534/full
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