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Cytotoxicity of Donor Natural Killer Cells to Allo-Reactive T Cells Are Related With Acute Graft-vs.-Host-Disease Following Allogeneic Stem Cell Transplantation

Objectives: The mechanism and immunoregulatory role of human natural killer (NK) cells in acute graft-vs.-host-disease (aGVHD) remains unclear. This study quantitatively analyzed the cytotoxicity of donor NK cells toward allo-reactive T cells, and investigated their relationship with acute GVHD (aGV...

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Principais autores: Lixia Sheng, Qitian Mu, Xiaoqing Wu, Shujun Yang, Huiling Zhu, Jiaping Wang, Yanli Lai, Hao Wu, Ye Sun, Yongxian Hu, Huarui Fu, Yi Wang, Kaihong Xu, Yongcheng Sun, Yanli Zhang, Ping Zhang, Miao Zhou, Binbin Lai, Zhijuan Xu, Minjie Gao, Yi Zhang, Guifang Ouyang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-07-01
Serier:Frontiers in Immunology
Fag:
natural killer cells
cytotoxicity
CD107a
graft vs. host disease
allogeneic hematopoietic stem cell transplantation
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2020.01534/full
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