Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons

Mutation of the ATL1 gene is one of the most common causes of hereditary spastic paraplegia (HSP), a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the corticospinal tract axons. Atlastin-1, the protein encoded by ATL1, is one of three mammalian atlastin...

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Autori principali:	Eliska Zlamalova, Catherine Rodger, Francesca Greco, Samuel R. Cheers, Julia Kleniuk, Aishwarya G. Nadadhur, Zuzana Kadlecova, Evan Reid
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-09-01
Serie:	Neurobiology of Disease
Soggetti:	Atlastin Hereditary spastic paraplegia Endoplasmic reticulum morphology Endosomal traffic Endosomal tubulation Lysosome
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0969996124001554
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