Structural and functional modifications of neuronal lipid rafts: implications for HIV-associated neurological disorders

Abstract Background HIV-associated neurological disorders (HAND) remain a prevalent co-morbidity of HIV infection. Growing evidence implicates the HIV protein Nef in this process, as Nef increases the abundance of neuronal lipid rafts - cholesterol- and sphingolipid-rich membrane microdomains linked...

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Detalhes bibliográficos

Principais autores:	Ying Fu, Kevin Huynh, Nigora Mukhamedova, Ben Crossett, Denise Tran, Siera Martinez, Anelia Horvath, Hong-Yin Wang, Ivan Castello-Serrano, Rosanna Ippolitto, Farhad Parhami, Peter J. Meikle, Ilya Levental, Michael Bukrinsky, Dmitri Sviridov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-02-01
Colecção:	Journal of Neuroinflammation
Assuntos:	HIV Nef Lipid rafts Neurodegeneration HIV-associated neurological disorder Neurons
Acesso em linha:	https://doi.org/10.1186/s12974-026-03730-5
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