Anti-Inflammatory Oxysterol, Oxy210, Inhibits Atherosclerosis in Hyperlipidemic Mice and Inflammatory Responses of Vascular Cells

Background and aims: We previously reported that Oxy210, an oxysterol-based drug candidate, exhibits antifibrotic and anti-inflammatory properties. We also showed that, in mice, it ameliorates hepatic hallmarks of non-alcoholic steatohepatitis (NASH), including inflammation and fibrosis, and reduces...

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Autori principali:	Frank Stappenbeck, Feng Wang, Satyesh K. Sinha, Simon T. Hui, Lia Farahi, Nigora Mukhamedova, Andrew Fleetwood, Andrew J. Murphy, Dmitri Sviridov, Aldons J. Lusis, Farhad Parhami
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2024-09-01
Serie:	Cells
Soggetti:	atherosclerosis NAFLD/NASH MAFLD/MASH oxysterols Oxy210 APOE*3-Leiden.CETP mouse model
Accesso online:	https://www.mdpi.com/2073-4409/13/19/1632
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