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Development and validation of an LC‒MS/MS method for the determination of cyclocreatine phosphate and its related endogenous biomolecules in rat heart tissues

Abstract The cardioprotective drug cyclocreatine phosphate has been awarded Food and Drug Administration-orphan drug designation for the prevention of ischemic injury to enhance cardiac graft recovery and survival in heart transplantation. Cyclocreatine phosphate is the water-soluble derivative of c...

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Principais autores: Ibrahim F. Abo-Elmagd, Amr M. Mahmoud, Medhat A. Al-Ghobashy, Marianne Nebsen, Mostafa A. Rabie, Ahmed F. Mohamed, Lamiaa A. Ahmed, Nesrine S. El Sayed, Reem K. Arafa, Robert Todd, Salwa A. Elgebaly
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-11-01
Serier:BMC Chemistry
Fag:
LC-MS/MS
Cyclocreatine phosphate
Cardioprotective
Endogenous biomolecules
Background subtraction
Online adgang:https://doi.org/10.1186/s13065-024-01304-1
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