Development and validation of an LC‒MS/MS method for the determination of cyclocreatine phosphate and its related endogenous biomolecules in rat heart tissues

Abstract The cardioprotective drug cyclocreatine phosphate has been awarded Food and Drug Administration-orphan drug designation for the prevention of ischemic injury to enhance cardiac graft recovery and survival in heart transplantation. Cyclocreatine phosphate is the water-soluble derivative of c...

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Hlavní autoři:	Ibrahim F. Abo-Elmagd, Amr M. Mahmoud, Medhat A. Al-Ghobashy, Marianne Nebsen, Mostafa A. Rabie, Ahmed F. Mohamed, Lamiaa A. Ahmed, Nesrine S. El Sayed, Reem K. Arafa, Robert Todd, Salwa A. Elgebaly
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-11-01
Edice:	BMC Chemistry
Témata:	LC-MS/MS Cyclocreatine phosphate Cardioprotective Endogenous biomolecules Background subtraction
On-line přístup:	https://doi.org/10.1186/s13065-024-01304-1
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