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Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis

Accumulating evidence highlights the pathogenetic role of human endogenous retroviruses (HERVs) in eliciting and maintaining multiple sclerosis (MS). Epigenetic mechanisms, such as those regulated by TRIM 28 and SETDB1, are implicated in HERV activation and in neuroinflammatory disorders, including...

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Main Authors: Pier-Angelo Tovo, Luca Marozio, Giancarlo Abbona, Cristina Calvi, Federica Frezet, Stefano Gambarino, Maddalena Dini, Chiara Benedetto, Ilaria Galliano, Massimiliano Bergallo
Format: Artigo
Language:Inglês
Published: MDPI AG 2023-03-01
Series:Viruses
Subjects:
multiple sclerosis
human endogenous retroviruses
TRIM28
SETDB1
pregnancy
Online Access:https://www.mdpi.com/1999-4915/15/3/710
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