Positive correlation between transcriptomic stemness and PI3K/AKT/mTOR signaling scores in breast cancer, and a counterintuitive relationship with PIK3CA genotype

A PI3Kα-selective inhibitor has recently been approved for use in breast tumors harboring mutations in PIK3CA, the gene encoding p110α. Preclinical studies have suggested that the PI3K/AKT/mTOR signaling pathway influences stemness, a dedifferentiation-related cellular phenotype associated with aggr...

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Auteurs principaux:	Ralitsa R. Madsen, Emily C. Erickson, Oscar M. Rueda, Xavier Robin, Carlos Caldas, Alex Toker, Robert K. Semple, Bart Vanhaesebroeck
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2021-11-01
Collection:	PLoS Genetics
Accès en ligne:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8584750/?tool=EBI
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