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The IQGAP1-claudin cell junction axis in cisplatin-induced epithelial damage

Abstract Dysfunction of epithelial cell contacts associates with a myriad of human diseases. Cisplatin is an effective antineoplastic agent where it interferes with DNA replication in proliferating cells, but it causes kidney epithelial damage by unclear mechanism(s). We hypothesized that cisplatin...

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Autori principali: Yusuf Barudi, Xiuzhen Fan, Kenneth W. Jenkins, Shubhra Kanti Dey, Lance Dworkin, Evgeny Yakirevich, Mahasin A. Osman
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2026-03-01
Serie:Cell Communication and Signaling
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Accesso online:https://doi.org/10.1186/s12964-026-02797-0
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