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PTEN‐mediated dephosphorylation of 53BP1 confers cellular resistance to DNA damage in cancer cells

Homologous recombination (HR) repair for DNA double‐strand breaks (DSBs) is critical for maintaining genome stability and conferring the resistance of tumor cells to chemotherapy. Nuclear PTEN which contains both phosphatidylinositol 3,4,5‐trisphosphate 3‐phosphatase and protein phosphatase plays a...

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Principais autores: Jianfeng He, Caihu Huang, Yanmin Guo, Rong Deng, Lian Li, Ran Chen, Yanli Wang, Jian Huang, Junke Zheng, Xian Zhao, Jianxiu Yu
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley 2024-03-01
סדרה:Molecular Oncology
נושאים:
53BP1
DNA damage repair
homologous recombination (HR) repair
PTEN
SUMOylation
גישה מקוונת:https://doi.org/10.1002/1878-0261.13563
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