Role of D-aminoacyl-tRNA deacylase beyond chiral proofreading as a cellular defense against glycine mischarging by AlaRS

Strict L-chiral rejection through Gly-cisPro motif during chiral proofreading underlies the inability of D-aminoacyl-tRNA deacylase (DTD) to discriminate between D-amino acids and achiral glycine. The consequent Gly-tRNAGly ‘misediting paradox’ is resolved by EF-Tu in the cell. Here, we show that DT...

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Autori principali:	Komal Ishwar Pawar, Katta Suma, Ayshwarya Seenivasan, Santosh Kumar Kuncha, Satya Brata Routh, Shobha P Kruparani, Rajan Sankaranarayanan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	eLife Sciences Publications Ltd 2017-03-01
Serie:	eLife
Soggetti:	translation genetic code amino acids chirality tRNA synthetase
Accesso online:	https://elifesciences.org/articles/24001
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