Chemosensory response to Pt-based chemotherapeutics via bitter taste receptors in vitro reveals a new mechanism for bitter taste disorders

Abstract Chemotherapeutics like platinum (Pt)-based drugs cause bitter taste disorders, which impair patients’ food intake and quality of life. However, the role of bitter taste receptors (TAS2Rs) remains unexplored, limiting the development of targeted treatments for this clinically impactful side...

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Autors principals:	Sofie Zehentner, Agnes Mistlberger-Reiner, Philip Pirkwieser, Noreen Orth, Valerie Boger, Kristin Kahlenberg, Johanna Kreißl, Christoph Grimm, Jakob Peter Ley, Veronika Somoza
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2026-01-01
Col·lecció:	Scientific Reports
Matèries:	Pt-based chemotherapeutic drugs Bitter taste disorders Bitter taste receptors (TAS2Rs) Homoeriodictyol Bitter masker Cellular uptake
Accés en línia:	https://doi.org/10.1038/s41598-026-35636-w
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