Chemosensory response to Pt-based chemotherapeutics via bitter taste receptors in vitro reveals a new mechanism for bitter taste disorders

Abstract Chemotherapeutics like platinum (Pt)-based drugs cause bitter taste disorders, which impair patients’ food intake and quality of life. However, the role of bitter taste receptors (TAS2Rs) remains unexplored, limiting the development of targeted treatments for this clinically impactful side...

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Váldodahkkit:	Sofie Zehentner, Agnes Mistlberger-Reiner, Philip Pirkwieser, Noreen Orth, Valerie Boger, Kristin Kahlenberg, Johanna Kreißl, Christoph Grimm, Jakob Peter Ley, Veronika Somoza
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Nature Portfolio 2026-01-01
Ráidu:	Scientific Reports
Fáttát:	Pt-based chemotherapeutic drugs Bitter taste disorders Bitter taste receptors (TAS2Rs) Homoeriodictyol Bitter masker Cellular uptake
Liŋkkat:	https://doi.org/10.1038/s41598-026-35636-w
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