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Engineering Gain-of-Function Analogues of the Spider Venom Peptide HNTX-I, A Potent Blocker of the hNaV1.7 Sodium Channel

Pain is a medical condition that interferes with normal human life and work and reduces human well-being worldwide. Human voltage-gated sodium channel NaV1.7 (hNaV1.7) is a compelling target that plays a key role in human pain signaling. The 33-residue peptide µ-TRTX-Hhn2b (HNTX-I), a member o...

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Furkejuvvon:
Váldodahkkit: Yunxiao Zhang, Qiuchu Yang, Qingfeng Zhang, Dezheng Peng, Minzhi Chen, Songping Liang, Xi Zhou, Zhonghua Liu
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: MDPI AG 2018-09-01
Ráidu:Toxins
Fáttát:
voltage-gated sodium channels
NaV1.7
spider venom
toxin
HNTX-I
engineering
Liŋkkat:http://www.mdpi.com/2072-6651/10/9/358
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