Codelivery of BCL2 and MCL1 Inhibitors Enabled by Phenylboronic Acid‐Functionalized Polypeptide Nanovehicles for Synergetic and Potent Therapy of Acute Myeloid Leukemia

Abstract Acute myeloid leukemia (AML) is the most refractory hematologic malignancy characterized by acute onset, rapid progression, and high recurrence rate. Here, codelivery of BCL2 (ABT199) and MCL1 (TW37) inhibitors using phenylboronic acid‐functionalized polypeptide nanovehicles to achieve syne...

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主要な著者:	Jiguo Xie, Xiaofei Zhao, Peng Zhang, Yueyue Zhang, Ru Cheng, Zhiyuan Zhong, Chao Deng
フォーマット:	Artigo
言語:	Inglês
出版事項:	Wiley 2023-03-01
シリーズ:	Advanced Science
主題:	acute myeloid leukemia BCL2 inhibitor BN coordination boronic ester bond MCL1 inhibitor synergetic therapy
オンライン･アクセス:	https://doi.org/10.1002/advs.202204866
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