Co-operation of MCL-1 and BCL-XL anti-apoptotic proteins in stromal protection of MM cells from carfilzomib mediated cytotoxicity

IntroductionBCL-2 family proteins are important for tumour cell survival and drug resistance in multiple myeloma (MM). Although proteasome inhibitors are effective anti-myeloma drugs, some patients are resistant and almost all eventually relapse. We examined the function of BCL-2 family proteins in...

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Hauptverfasser:	Daria Galas-Filipowicz, Selina J. Chavda, Jia-Nan Gong, David C. S. Huang, Asim Khwaja, Kwee Yong
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-04-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	carfilzomib drug resistance stromal cells anti-apoptotic proteins Mcl-1 BCL-XL
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1394393/full
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