Metformin relieves bone cancer pain by reducing TGFβRI-TRPV1 signaling in rats

Common cancer complications include bone cancer pain (BCP), which was not sufficiently alleviated by traditional analgesics. More safe and effective therapy was urgent needed. Metformin relieved osteoarthritis pain, but the analgesia of Metformin in BCP was not well studied. The study aimed to explo...

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Detalhes bibliográficos

Principais autores:	Fang Zhou, He-Ya Qian, Ke Wang, Yong-Juan Gu, Pei-Lin Liu, Ling Zhang, Long Chen, Yu Song, Ya-Nan Chen, Hai-Long Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-08-01
coleção:	Heliyon
Assuntos:	Bone cancer pain Metformin TGFβ1 TGFβRI TRPV1
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2405844024110225
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