Automated mapping of DNA replication fork progression in human cells with ForkML

Abstract Current approaches to mapping fork progression in the human genome suffer from drastically low throughput. Here, we introduce ForkML, a nanopore sequencing-based method automatically positioning thousands of individual fork velocities by tracking BrdU incorporation into replicating DNA afte...

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Detalhes bibliográficos

Principais autores:	Victoria Rojat, Diletta Ciardo, Alan Tourancheau, Florence Proux, Etienne Jean, Jean-Michel Arbona, Benjamin Audit, Gael A. Millot, Frédéric Bonhomme, Paola B. Arimondo, Olivier Hyrien, Benoît Le Tallec
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2026-01-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-026-68750-4
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