Automated mapping of DNA replication fork progression in human cells with ForkML
Abstract Current approaches to mapping fork progression in the human genome suffer from drastically low throughput. Here, we introduce ForkML, a nanopore sequencing-based method automatically positioning thousands of individual fork velocities by tracking BrdU incorporation into replicating DNA afte...
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| Hlavní autoři: | , , , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Portfolio
2026-01-01
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| Edice: | Nature Communications |
| On-line přístup: | https://doi.org/10.1038/s41467-026-68750-4 |
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