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The RNA-Binding Domain NS1 of Influenza as an Antiviral Target: From Evolutionary Conservation Mapping to Experimental Validation

Non-structural protein 1 (NS1) of influenza A virus is a multifunctional virulence factor and represents a promising anti-influenza target, considering its conserved and druggable structure. As antiviral target, NS1-RNA-binding domain (RBD) remains unexplored, despite its critical role in replicatio...

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Principais autores: Luis André Santos, João Trigueiro-Louro, Helena Rebelo-de-Andrade
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-02-01
Serier:Viruses
Fag:
influenza A virus
antiviral target
druggable pockets
mutagenesis
viral replication
viral fitness
Online adgang:https://www.mdpi.com/1999-4915/18/3/279
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